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. 2011 Apr 19;8:181. doi: 10.1186/1743-422X-8-181

Figure 6.

Figure 6

A proposed model for the molecular mechanism of NS1-induced apoptosis. Binding of NS1 protein to Hsp90 might compete off the Apaf-1, resulting in the oligomerization of Apaf-1 which promotes the interaction between Apaf-1 and Cyt c and lead to the activation of caspase 9 and caspase 3 and thus the cell apoptosis occur.