Table 5.

Diagnostic accuracy of the ALP, bilirubin, albumin, platelet count and fibrosis-cirrhosis index (FCI) for the prediction of F0-F1 stage and hepatic cirrhosis in chronic HCV infected patients (n = 157)

Marker Cutoff	Interpretation		AUC [95% CI]	Spe%	Sen%	PPV%	NPV%
ALP
< 120	F0-F1 (n = 68)	F2-F4 (n = 89)	0.829 [0.760-0.897]	69.6	85.2	68.2	86.1
	58/10	27/62
> 240	F4 (n = 21)	F0-F3 (n = 136)	0.931 [0.882-0.981]	91.9	80.9	60.7	96.9
	17/4	11/125
Bilirubin
< 0.95	F0-F1 (n = 68)	F2-F4 (n = 89)	0.729 [0.643-0.815]	68.1	85.2	67.4	85.7
	58/10	28/60
> 1.5	F4 (n = 21)	F0-F3 (n = 136)	0.889 [0.816-0.962]	95.5	66.6	70	94.8
	14/7	6/130
Albumin
> 4.1	F0-F1 (n = 68)	F2-F4 (n = 89)	0.812 [0.738-0.886]	67.4	100	70.1	100
	68/0	29/60
< 3.85	F4 (n = 21)	F0-F3 (n = 136)	0.879 [0.796-0.962]	92.6	71.4	60	95.4
	15/6	10/126
Platelet count
> 150	F0-F1 (n = 68)	F2-F4 (n = 89)	0.935[0.900-0.970]	69.6	98.5	71.2	98.4
	67/1	27/62
< 100	F4 (n = 21)	F0-F3 (n = 136)	0.990[0.977-1.002]	98.5	80.9	89.4	97.1
	17/4	2/134
FCI
< 0.130	F0-F1 (n = 68)	F2-F4 (n = 89)	0.932[0.895-0.969]	86.5	80.8	82.1	85.5
	55/13	12/77
> 1.25	F4 (n = 21)	F0-F3 (n = 136)	0.996[0.989-1.002]	100	85.7	100	97.8
	18/3	0/136

Spearman rank correlation coefficient (R-index) for ALP = 0.716, bilirubin = 0.597, albumin = -0.700, platelet count = -0.817 and FCI = 0.818.