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. 2011 May 19;7(5):e1002045. doi: 10.1371/journal.ppat.1002045

Figure 4. Effect of peptide stimulation and simultaneous 2B4 cross-linking on the expansion of HCV-specific CD8+ T cells in patients with chronic hepatitis C.

Figure 4

Exemplary FACS plots from six different day10 cell lines analyzed are shown, frequency of HCV-tetramer+ cells of total CD8+ T cells are indicated. Samples were divided according to the direct ex vivo expression intensity (MFI) of 2B4 on HCV-specific CD8+ T cells into 2B4 MFI low (left panel) and 2B4 MFI high (right panel). Cross-linking of 2B4 resulted in an increased frequency of HCV-specific CD8+ T cells in those samples with low 2B4 expression ex vivo, while for those samples with high expression no increase or even a decrease of proliferation was observed.