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. 2011 May 19;6(5):e19889. doi: 10.1371/journal.pone.0019889

Figure 4. Expression of T cell transcription factors, T-bet+(Th1), GATA3+(Th2), RORγt+(Th17) and Foxp3+(Tregs) cells in the CD4+CD25− cells in lung during allergic inflammation.

Figure 4

A) Number of lung CD4+CD25− cells (per gram tissue) expressing T-bet, GATA-3, RORγt and Foxp3 after exposure of mice to PBS or OVA. Data is shown as mean ± SEM, n  =  5–8 mice/group (*** p<0.001, ** p<0.01). B) Fold change of the total number of lung cells expressing the four different transcription factors (T-bet, GATA-3, RORγ and Foxp3) in CD4+CD25− after exposure of mice to OVA compared to PBS. C) Pie chart showing the relative presence of Th1 (T-bet+), Th2 (GATA-3+), Th17 (RORγt+) and Treg (Foxp3+) T cells expressed as percentage of CD4+CD25− cells in OVA and PBS exposed animals. TF = transcription Factor. D) The fold change of the relative presence of Th1 (T-bet+), Th2 (GATA-3+), Th17 (RORγt+ ) and Treg (Foxp3+) T cells expressed as percentage of CD4+CD25− cells after exposure of mice to OVA compared to PBS.