Figure 4. Immunoprecipitation of PRIOC1 mAb (5 µg/ml) with human, bovine and ovine PrP from brain homogenates (1% w/v).

PRIOC1 strongly immunocaptures precipitates from human type 4 CJD homogenate but not PrPC with PK treatment. In contrast, PRIOC1poorly immunocaptures precipitates from bovine and ovine PrPC and PrPSc with PK treatment. Representative of three experiments.