Table 2. Differential treatment of PrPSc-infected material prior to adsorption to the Dynabeads used to produce PRIOC mAbs.
| Fusion partner | Stability | Immunogen | PrPSc treatment/binding |
| PRIOC1 | |||
| NS/0 | ‘Unstable’ | PrPSc-Dynabeads | None |
| PRIOC2 | |||
| SP2/0 | Stable | PrPSc-Dynabeads | None |
| PRIOC3 | |||
| SP2/0 | Stable | PrPSc-Dynabeads | Heat-treated |
| PRIOC4 | |||
| SP2/0 | Stable | PrPSc-Dynabeads | Congo red |
All PRIOC mAbs have been generated in Prn-p0/0 mice immunised with PrP-Dynabeads following treatment with heat, Congo red or no treatment.