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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Mar 24;31(6):1260–1267. doi: 10.1161/ATVBAHA.110.220202

Figure 4.

Figure 4

Inhibition of CXCR2 and AhR decreases plaque formation in ApoE−/− mice. Mice fed regular chow and received (A&E) corn oil (Ctrl) or (B&F) TCDD for 60 days. ApoE−/− mice were treated with (C) SB225002 in the absence or (D) presence of TCDD or treated with (G) CH223191 in the absence or (H) presence of TCDD. Serial cross sections of representative aorta arches from six mice were visualized by H&E staining. The animals in each group showed a similar phenotype (see also Fig. SIV). Arrows indicate formation of early atherosclerotic lesions.