. Author manuscript; available in PMC: 2012 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Mar 24;31(6):1260–1267. doi: 10.1161/ATVBAHA.110.220202

Table 1. Induction of inflammatory marker genes in aorta of ApoE−/− mice.

Mice were treated with a single i.p. injection of 15 µg/kg and a weekly dose of 1 µg/kg TCDD for 60 days. ApoE−/− mice were fed a regular chow (reg. chow) or a high-fat diet (HFD). mRNA levels of CYP1A1, CXCL5, CXCR2, KC, MCP-1, MMP-12, F4/80, P-Selectin, and VEGF were quantified using real-time PCR. Values represent means of three animals per group.

	ApoE−/− (reg. chow)		ApoE−/− (HFD)

Gene	Control	TCDD	Control	TCDD
CYP1A1	1.2 ± 0.5	207.7 ± 6.5^*	1.5 ± 0.9	210.0 ± 9.0^*
CXCL5	1.5 ± 0.6	3.8 ± 1.2^*	3.7 ± 0.4^**	12.5 ± 0.9^*
CXCR2	1.1 ± 0.3	1.2 ± 0.4	1.3 ± 0.3	1.2 ± 0.6
KC^a	1.1 ± 0.4	8.3 ± 0.6^*	11.7 ± 0.7^**	28.4 ± 3.1^*
MCP-1	1.2 ± 0.2	5.7 ± 0.9^*	3.7 ± 0.4^**	18.4 ± 0.8^*
MMP-12	1.3 ± 0.4	29.2 ± 2.3^*	27.00 ± 2.1^**	52.1 ± 3.6^*
F4/80	1.0 ± 0.2	3.6 ± 0.4^*	2.6 ± 0.4^**	7.7 ± 0.6^*
P-Selectin	1.2 ± 0.3	2.7 ± 0.3^*	2.8 ± 0.4^**	3.4 ± 0.5
VEGF	1.2 ± 0.5	2.9 ± 0.4^*	2.5 ± 0.3^**	3.2 ± 0.8

Values are significantly different from control;

^**

values are different from ApoE−/− control mice fed a regular chow, (p < 0.01).

KC is the orthologue of human IL-8.