Table 1.

Adenosquamous carcinoma of the head and neck: clinicopathologic data and immunohistochemical and in situ hybridization results

Case	Location	Age/Sex	T and N-stage	Overall stage	Distant metastases? (site)	Follow-up (months)	HPV DNA	HPV RNA (Type)	p16	p53
1	Paranasal sinus	82/M	NA	NA	Unknown	DWD (2)	N	N	2+	P
2	Tongue	42/M	T2/N0	II	Yes (mediastinum)	DWD (34)	N	N	N	P
3	Tongue	65/F	T1/N0	I	No	NA	N	N	1+	P
4	Soft palate/Tonsil	62/M	T2/N2	IV	Yes (neck skin)	DWD (36)	N	N	N	P
5	Larynx	59/M	T4/N0	IV	Yes (lung and liver)	DWD(8)	N	N	N	P
6	Tonsil	63/M	T2/N2	IV	No	AWOD(103)	P	P (16)	4+	P
7	Larynx	43/M	T2/N0	II	Yes (lung)	AWOD (128)	N	NS	4+	N
8	Larynx	60/M	T2/N0	II	No	AWOD (54)	N	N	N	N
9	Tongue	48/M	T2/N1	III	No	AWOD (3.5)	N	N	4+	N
10	Larynx	69/M	T2/N2	IV	No	DWD (1.5)	N	N	N	P
11	Hypopharynx	52/M	T3/N2	IV	No	DWOD (65)	P	N	N	P
12	Tonsil	46/M	T1/N2	IV	No	AWOD (34)	P	P (16)	4+	P
13	Larynx	51/M	T1/N0	I	No	AWOD (42)	N	N	N	N
14	Nose/hard palate/maxilla	52/M	T4/N0	IV	No	DWD (4.5)	P	P (HR)	4+	P
15	Larynx	66/M	T2/N0	II	No	AWD (26)	N	NS	4+	P
16	Larynx	58/M	T4/N0	IV	No	NA	P	N	N	P
17	Tongue	87/F	T2/N2	IV	No	AWD(9)	N	N	N	P
18	Nasal cavity	62/M	T1/N0	I	No	AWOD(26)	N	NS	3+	P

M Male; F Female; NA Not available; DWD Died with disease; DWOD Died without disease; AWD Alive with disease; AWOD Alive without disease; P Positive; N Negative; HPV Human papillomavirus; DNA Deoxyribonucleic acid; RNA Ribonucleic acid; NS Not scoreable; 16 Human papillomavirus 16; HR human papillomavirus, non-type 16 high risk type

Bold text in follow up column indicates patients who died in follow up; bold text in the HPV DNA, HPV RNA, and p16 columns indicate those cases demonstrating HPV