Table 2.
Reflux Symptom Index (RSI), GERD Health-related Quality of Life (GERD-HRQL), and regurgitation scores before esophagogastric transoral incisionless fundoplication (TIF) surgery while on PPIs and at a median 6 (3–14) months after surgery
| Pre-TIF on PPIs | Post-TIF off PPIs | p value | |
|---|---|---|---|
| RSI scores | |||
| Median (range) | 25 (5–38) n = 23 | 10 (0–39) n = 32 | 0.002 |
| Mean (SEM) | 22.8 (2.2) n = 23 | 12.9 (1.8) n = 32 | 0.003 |
| n (%) abnormala | 20/23 (87%) | 11/32 (34%) | <0.001 |
| n (%) improved by ≥50%b | 14/22 (64%) | ||
| n (%) normalizedc | 11/21 (52%) | ||
| GERD-HRQL scores | |||
| Median (range) | 16 (0–29) n = 21 | 4 (0–27) n = 32 | 0.001 |
| Mean (SEM) | 15.3 (2.1) n = 21 | 5.0 (1.1) n = 32 | 0.002 |
| n (%) abnormala | 17 (81%) | 13 (41%) | <0.001 |
| n (%) improved by ≥50%b | 16/20 (80%) | ||
| n (%) normalizedd | 10/20 (50%) | ||
| Regurgitation scores | |||
| Median (range) | 10 (0–26) n = 21 | 1 (0–25) n = 32 | 0.005 |
| Mean (SEM) | 11.2 (2.0) n = 21 | 4.3 (1.2) n = 32 | 0.006 |
| n (%) abnormala | 11/21 (52%) | 6/32 (19%) | 0.016 |
| n (%) improved by ≥50%b | 14/20 (70%) | ||
| n (%) normalizedd | 8/13 (62%) | ||
| Satisfaction indexe | |||
| n (%) satisfied | 0/23 (0%) | 21/32 (66%) | <0.001 |
| n (%) neutral | 4/23 (19%) | 4/32 (12%) | <0.001 |
| n (%) dissatisfied | 17/23 (81%) | 7/32 (22%) | <0.001 |
p values <0.05 indicate significant differences between medians (Mann–Whitney U test), means (paired t test), and ratios (Fisher’s exact test)
aAbnormal if any individual score >2
bCompared to baseline on PPIs
cNormalized RSI score defined by a total score of ≤13 with each question evaluated as eliminated or rare (score ≤2)
dNormalized if none of the abnormal scores at baseline is >2 at follow-up
eSatisfaction index determined using GERD-HRQL indicates patient satisfaction with current health condition