Fig. 5.

Role of COX-1 and COX-2 in LPS-induced behavioural changes. Effect of the selective COX-1 inhibitors piroxicam (10 mg/kg) and sulindac (10 mg/kg), or the selective COX-2 inhibitors nimesulide (10 mg/kg) and nuflimic acid (10 mg/kg) pre-treatment on burrowing activity measured 1–3 h following intra-peritoneal injection of LPS. Values of behaviour are expressed as percentage of baseline ± SEM. One-way ANOVA followed by Dunnett’s post-test was used to analyse if behavioural changes were different from ‘saline-treated’ mice. A total of 26 mice were used in this experiment: saline n = 5, LPS alone n = 5, piroxicam + LPS n = 5, sulindac + LPS n = 3, nimesulide + LPS n = 5, nuflimic acid + LPS n = 3 per group. ∗p < 0.05, ∗∗p < 0.01.