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. 2011 May 14;17(18):2288–2301. doi: 10.3748/wjg.v17.i18.2288

Table 5.

Antioxidant effects of silybin[65-75]

Doses Cells Targets
From 10 to 100 μmol/L Hepatocytes Decreased formation of reactive oxygen species from mitochondria; iron chelator
HepG2 Decreased formation of superoxide anion
Mean dose with documented effects: 20 μmol/L Kupffer cells Decrease of NO production
Monocytes Scavenger of lipodienyl, methyl, trichloromethyl radicals
Endothelial cells Decrease of hydrogen peroxide concentration
Cancer cells Block of membrane lipid peroxidation