Table 2.
Genotype specific risks from stage 1 (SEA, UKO and MAL)
| All subtypes |
Serous |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | tSNP | Controls1 | Cases1 | Serous cases |
HetOR2 (95% CI) | HomOR2 (95% CI) | p-trend | HetOR2 (95% CI) | HomOR2 (95% CI) | p-trend |
| AXIN2 | rs11079571 | 1,206 | 839 | 326 | 1.23 (1.00–1.51) | 1.73 (0.99–3.01) | 0.038 | 1.22 (0.92–1.63) | 1.74 (0.84–3.63) | 0.11 |
| CASP5 | rs518604 | 1,195 | 438 | 270 | 1.39 (1.06–1.81) | 1.44 (1.05–1.97) | 0.012 | 1.36 (0.98–1.88) | 1.45 (0.99–2.11) | 0.031 |
| RBBP8 | rs4474794 | 2,895 | 1,764 | 829 | 0.94 (0.82–1.07) | 0.88 (0.72–1.06) | 0.21 | 0.83 (0.70–0.98) | 0.80 (0.63–1.03) | 0.032 |
| RUVBL1 | rs13063604 | 1,724 | 1,266 | 537 | 1.14 (0.97–1.34) | 1.39 (1.02–1.89) | 0.019 | 1.42 (1.15–1.74) | 1.63 (1.10–2.42) | 0.0002 |
| RUVBL1 | rs7650365 | 2,672 | 1,645 | 769 | 1.08 (0.93–1.26) | 0.86 (0.72–1.03) | 0.11 | 0.97 (0.80–1.17) | 0.74 (0.58–0.93) | 0.009 |
| STAG3 | rs1637001 | 2,967 | 1,784 | 843 | 0.86 (0.76–0.98) | 0.92 (0.73–1.16) | 0.07 | 0.84 (0.71–0.99) | 0.77 (0.56––1.05) | 0.018 |
Bold indicates significant p values <0.05.
1
The differences in the numbers of cases and controls between tSNPs reflect the exclusion of data from some studies that did not pass genotyping quality control criteria.
2
OR and CI compared to common homozygote.
Abbreviations: OR: odds ratio; CI: confidence interval.