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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Nat Commun. 2011 May;2:315. doi: 10.1038/ncomms1308

Figure 6. An amiloride-sensitive channel(s) mediates mechanosensitive currents in PVD.

Figure 6

(a) Mechanical stimulation evokes mechanosensitive currents in PVD. Such currents persisted in mec-10(tm1552). Clamping voltage: −75 mV. Touch was directed to the primary dendrite of PVD. Displacement: 20 μm. A 10 μm displacement was needed to evoke mechanosensitive currents in PVD, a much higher threshold than that in PDE. PVD in mec-10(tm1552) animals displayed a similar sensitivity (threshold).

(b) Bar graphs. Touch-evoked mechanosensitive currents in PVD were sensitive to amiloride (200 μM) but persisted in mec-10(tm1552), as well as in mec-10(tm1552); unc-13(e51) double mutant animals. n≥5. Error bars: SEM.

(c) I–V relations of mechanosensitive currents in PVD. n≥5. Error bars: SEM.