Figure 4. 50 mg/kg gefitinib, in addition to PGIS overexpression, significantly decreases tumor multiplicity.
PGIS overexpressors treated with gefitinib 50 mg/kg thrice weekly show decreased tumor multiplicity, while a dose of 100 mg/kg did not alter tumor development. All PGIS overexpressors had lower tumor multiplicity and volume compared to wildtype mice, as previously described.