Figure 2.

Schematic showing how prenatal maternal 5-HT1A receptor deficiency may lead to alterations in offspring hippocampal development and increased anxiety-related behavior. 5-HT1A receptor deficiency in the mouse mother is signaled across the placenta during embryonic development and transmuted to the developing brain. This prenatal reprogramming results in delayed maturation in the early postnatal dentate gyrus, which may contribute to changes in hippocampal network formation and ultimately to increased anxiety-related behavior.