Figure 4.

Maternal and offspring fmr1 genotype effects on locomotor activity. Locomotor activity is increased in genetically unaffected animals due to maternal FMRP deficit, and this behavioral effect is further enhanced by the offspring's own lack of FMRP. Maternal FMRP deficit increases GABA_B receptor and decreases D2 autoreceptor function and this effect is not further modified by the offspring's own fmr1 expression suggesting that these neurochemical changes are specifically associated with the maternal deficit in FMRP.