Table 1.
Resting cardiopulmonary variables
| V̇e, min | Vt, liters | RR, beats/min | PetO2, mmHg | PetCO2, mmHg | SpO2,% | HR, beats/min | Q, l/min | MABP, mmHg | |
|---|---|---|---|---|---|---|---|---|---|
| Normoxia | |||||||||
| Placebo | |||||||||
| Mean | 8.7 | 0.62 | 16 | 79.2 | 36.2 | 95 | 63 | 6.0 | 92 |
| SD | 2.0 | 0.17 | 3 | 4.8 | 3.2 | 1 | 9 | 1.1 | 12 |
| Acetazolamide | |||||||||
| Mean | 9.6 | 0.66 | 15 | 81.8 | 34.5* | 96 | 63 | 5.9 | 90 |
| SD | 1.7 | 0.13 | 4 | 3.2 | 2.3 | 1 | 12 | 0.9 | 12 |
| Dexamethasone | |||||||||
| Mean | 10.2 | 0.66 | 16 | 81.1 | 34.8* | 95 | 71*‡ | 7.0*‡ | 90 |
| SD | 2.4 | 0.15 | 3 | 3.7 | 3.2 | 1 | 13 | 1.3 | 8 |
| Hypoxia | |||||||||
| Placebo | |||||||||
| Mean | 12.6† | 0.74† | 17 | 44.6† | 31.0† | 78† | 97† | 8.3† | 89 |
| SD | 3.3 | 0.19 | 4 | 5.1 | 3.3 | 8 | 11 | 1.6 | 13 |
| Acetazolamide | |||||||||
| Mean | 13.3† | 0.79† | 18† | 48.1*† | 27.6*† | 82*† | 94† | 7.5† | 84 |
| SD | 2.8 | 0.23 | 4 | 3.0 | 2.0 | 5 | 11 | 1.7 | 12 |
| Dexamethasone | |||||||||
| Mean | 13.1† | 0.84† | 17 | 43.1†‡ | 31.0†‡ | 77†‡ | 97† | 9.1†§ | 85† |
| SD | 2.6 | 0.22 | 4 | 4.6 | 2.3 | 8 | 10 | 1.9 | 12 |
Values are means ± SD, n =20. V̇e, minute ventilation; Vt, tidal volume; RR, respiratory rate; PetO2, partial pressure O2; PetCO2, partial pressure CO2; SpO2, arterial saturation; HR, heart rate; Q, cardiac output; MABP, mean arterial blood pressure.
*
Different from PL (P < 0.01 to control for type I error);
†
different from normoxia (P < 0.01);
‡
different from Acetazolamide (P < 0.01).