Fig. 1.

Attenuation of sodium nitroprusside (SNP) induced vasodilation by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ). SNP (50 μM) increased cutaneous vascular conductance (CVC) to 53 ± 5% maximum CVC at microdialysis sites perfused with Ringer solution and to 56 ± 5% maximum CVC at sites perfused with 2% DMSO (P < 0.01 vs. baseline sites). The addition of 1 mM ODQ dissolved in 2% DMSO solution attenuated this vasodilation to 22 ± 5% maximum CVC. Values are means ± SE. P < 0.01, ODQ vs. Ringer or 2% DMSO with SNP. P > 0.05 vs. Ringer or 2% DMSO baseline sites.