Fig. 2.

Whole body heat stress protocol. This protocol was designed to examine the effects of antagonism of soluble guanylyl cyclase by ODQ on the reflex vasodilation induced by whole body heat stress. Three intradermal microdialysis sites were perfused with either 1 mM ODQ in 2% DMSO, 2% DMSO, or Ringer solution alone. Maximal cutaneous vasodilation was achieved at all sites at the end of the study by perfusion with 58 mM SNP. The perfusion rate at all microdialysis sites was 2 μl/min. AVD, active vasodilator.