Fig. 3.
Local skin warming protocol. This protocol was designed to examine the effects of antagonism of soluble guanylyl cyclase by ODQ on the vasodilation induced by local warming of the skin. Three intradermal microdialysis sites were perfused with 1 mM ODQ in 2% DMSO, 2% DMSO, or Ringer solution. Maximal cutaneous vasodilation was achieved at all sites at the end of the study by perfusion with 58 mM SNP. The perfusion rate at all microdialysis sites was 2 μl/min. Tloc, local skin temperature.