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CVC responses to the local skin warming protocol in one subject. In the first part of the protocol, Tloc was controlled at 34°C. Perfusion with 1 mM ODQ and 2% DMSO began 9 min into the study. At 66 min into the study, Tloc was increased to 41.5°C. Perfusion with 58 mM SNP began at 111 min.