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Semaphorins and their receptors. Shown here are the five classes of vertebrate Semaphorins and the major holoreceptor complexes required for Semaphorin-mediated repulsive and attractive guidance responses. Not shown are invertebrate transmembrane class 1 and secreted class 2 Semaphorins, and several non-Plexin/Neuropilin Semaphorin receptors. The key defines distinct molecular domains found in these proteins.
