. 2011 Feb 28;589(Pt 9):2245–2260. doi: 10.1113/jphysiol.2010.200659

Table 1.

Changes in persistent inward current (PIC) parameters with maturation and superoxide dismutase-1 (SOD1) mutation

	WT P0–5		SOD1 P0–5		WT P6+		SOD1 P6+

	Mean	SD n	Mean	SD n	Mean	SD n	Mean	SD n	Significance of age	Significance of SOD1
Total PIC onset voltage (mV)	−46	±5	−46	±6	−42	±10	−45	±8	—	—
		13		17		20		20
Total PIC peak (mV)	−22	±7	−22	±5	−18	±9	−19	±5	↑	—
		13		17		20		20
Total PIC amplitude (pA)	−149	±96	−294	±153	−214	±127	−450	±349	↑	↑↑↑
		13		17		20		20
Na⁺ PIC onset voltage (mV)	−44	±5	−45	±6	−43	±6	−44	±6	—	—
		14		17		19		16
Na⁺ PIC peak (mV)	−17	±5	−20	±4	−18	±7	−15	±5	—	—
		14		17		19		16
Na⁺ PIC amplitude (pA)	−132	±75	−229	±126	−179	±99	−450	±343	↑	↑↑↑
		14		17		19		16
Ca²⁺ PIC onset voltage (mV)	−43	±8	−43	±7	−40	±12	−43	±9	—	—
		15		19		21		24
Ca²⁺ PIC peak (mV)	−25	±9	−26	±9	−22	±11	−21	±7	↑	—
		15		19		21		24
Ca²⁺ PIC amplitude (pA)	−47	±38	−79	±56	−49	±49	−109	±69	—	↑↑↑
		15		19		21		24
Total PIC/C (pA pF⁻¹)	−0.52	±0.27	−1.20	±1.04	−0.70	±0.40	−1.56	±1.39	—	↑↑↑
		13		17		20		20
Na⁺ PIC/C (pA pF⁻¹)	−0.48	±0.25	−1.00	±1.11	−0.61	±0.34	−1.56	±1.36	—	↑↑
		14		17		19		16
Ca²⁺ PIC/C (pA pF⁻¹)	−0.18	±0.18	−0.28	±0.21	−0.16	±0.14	−0.35	±0.23	—	↑↑
		15		19		20		24
Capacitance (pF)	273	±81	324	±156	321	±83	326	±93	—	—
		24		25		31		31

The rows contain the values for the total, Na⁺ and Ca²⁺ PIC, and PIC normalized to capacitance (C). The PIC properties include the voltage of onset, the voltage of its peak and the amplitude of the current at peak. Also shown are the values for whole-cell capacitance. The mean value ± SD for each group is listed with the number of samples (n). The number of arrows in the rightmost two columns indicates significance, as follows: ↑ indicates 0.05 > P≥ 0.01; ↑↑ indicates 0.01 > P≥ 0.001; and ↑↑↑ indicates P < 0.001.