. 2011 Feb 28;589(Pt 9):2245–2260. doi: 10.1113/jphysiol.2010.200659

Table 2.

Changes in active and passive properties with maturation and SOD1 mutation

	WT P0–5		SOD1 P0–5		WT P6+		SOD1 P6+

	Mean	SD n	Mean	SD n	Mean	SD n	Mean	SD n	Significance of age	Significance of SOD1
V_thresh (mV)	−29	±5	−27	±5	−30	±7	−30	±5	—	—
		14		16		18		26
AP overshoot (mV)	28	±7	29	±10	30	±11	32	±7	—	—
		19		19		20		28
AP duration (ms)	1.5	±0.6	1.1	±0.3	1.1	±0.3	0.9	±0.2	↓↓↓	↓↓↓
		19		19		20		28
AP rise (mV ms⁻¹)	75	±26	95	±33	95	±31	106	±20	↑↑	↑
		19		19		20		28
AP fall (mV ms⁻¹)	39	±13	56	±19	54	±16	72	±17	↑↑↑	↑↑↑
		19		19		20		28
ISI 1–3/SS ISI (%)	70	±34	66	±22	57	±32	71	±25	—	—
		16		15		17		15
AHP amplitude (mV)	9.4	±2.3	8.9	±2.3	9.2	±3.0	10.8	±2.9	—	—
		15		15		11		17
AHP τ (ms)	40	±18	28	±15	28	±10	24	±10	↓	↓
		15		14		11		17
ADH amplitude (mV)	5.5	±2.7	2.9	±2.5	2.5	±1.5	1.9	±1.6	↓↓	↓
		7		13		13		17
Conductance (nS)	16	±6	20	±10	26	±10	32	±14	↑↑↑	↑
		24		25		30		32
I_on (pA)	368	±175	443	±281	664	±374	903	±519	↑↑↑	—
		16		18		18		27
I_off (pA)	420	±201	486	±293	781	±425	983	±583	↑↑↑	—
		16		18		18		27
ΔI (pA) (ms)	52	±134	44	±86	117	±195	80	±243	—	—
		16		18		18		27
F–I_asc (Hz nA⁻¹)	35	±15	40	±23	31	±15	33	±17	—	—
		15		18		17		27
F–I_desc (Hz nA⁻¹)	32	±14	40	±28	33	±21	35	±24	—	—
		13		18		16		27
RMP (mV)	−57	±4	−56	±4	−60	±6	−60	±5	↓↓↓	—
		16		19		20		27

Shown here are the properties of the action potential (AP), including the voltage at AP threshold (V_thresh), AP overshoot and the interspike intervals (ISIs) of first three APs of a square current pulse normalized to steady state (ISI 1–3/SS ISI). The following rows include conductance, the ascending and descending slope of the F–I curves (F–I_asc, F–I_desc) and the resting membrane potential (RMP). The mean value ± SD for each group is listed with the number of samples (n). The number of arrows in the rightmost two columns indicates significance, as follows: ↑ indicates 0.05 > P≥ 0.01; ↑↑ indicates 0.01 > P≥ 0.001; and ↑↑↑ indicates P < 0.001.