Table 3.
Changes in active and passive properties between the high-PIC and low-PIC SOD1 motoneurons
| Low-PIC SOD1 | High-PIC SOD1 | ||||
|---|---|---|---|---|---|
| Mean | SD n | Mean | SD n | Significance | |
| Total onset voltage (mV) | −46 | ±7 | −44 | ±6 | — |
| 28 | 9 | ||||
| Total peak (mV) | −22 | ±4 | −16 | ±6 | ↑ |
| 28 | 9 | ||||
| Total amplitude (pA) | −246 | ±109 | −791 | ±265 | ↑↑↑ |
| 28 | 9 | ||||
| Na+ PIC onset voltage (mV) | −44 | ±6 | −46 | ±6 | — |
| 24 | 9 | ||||
| Na+ PIC peak (mV) | −18 | ±5 | −17 | ±4 | — |
| 24 | 9 | ||||
| Na+ PIC amplitude (pA) | −200 | ±95 | −696 | ±275 | ↑↑↑ |
| 24 | 9 | ||||
| Ca2+ PIC onset voltage (mV) | −44 | ±8 | −39 | ±9 | — |
| 34 | 9 | ||||
| Ca2+ PIC peak (mV) | −24 | ±8 | −18 | ±7 | ↑ |
| 34 | 9 | ||||
| Ca2+ PIC amplitude (pA) | −87 | ±67 | −129 | ±39 | ↑ |
| 34 | 9 | ||||
| Total PIC/C (pA pF−1) | −0.91 | ±0.77 | −2.90 | ±1.22 | ↑↑↑ |
| 28 | 9 | ||||
| Na+ PIC/C (pA pF−1) | −0.79 | ±0.91 | −2.55 | ±1.18 | ↑↑ |
| 24 | 9 | ||||
| Ca2+ PIC/C (pA pF−1) | −0.28 | ±0.21 | −0.48 | ±0.20 | ↑ |
| 34 | 9 | ||||
| Capacitance (pF) | 331 | ±130 | 294 | ±86 | — |
| 47 | 9 | ||||
| Vthresh (mV) | −29 | ±5 | −29 | ±4 | — |
| 34 | 8 | ||||
| RMP (mV) | −58 | ±5 | −61 | ±5 | — |
| 37 | 9 | ||||
| AP overshoot (mV) | 30 | ±9 | 33 | ±4 | — |
| 38 | 9 | ||||
| AP duration (ms) | 1.0 | ±0.3 | 0.7 | ±0.1 | ↓↓↓ |
| 38 | 9 | ||||
| AP rise (mV ms−1) | 100 | ±28 | 111 | ±13 | — |
| 38 | 9 | ||||
| AP fall (mV ms−1) | 62 | ±18 | 81 | ±15 | ↑↑ |
| 38 | 9 | ||||
| ISI 1–3/SS ISI (%) | 66 | ±20 | 81 | ±32 | — |
| 24 | 6 | ||||
| AHP amplitude (mV) | 10.0 | ±2.6 | 9.3 | ±3.8 | — |
| 27 | 5 | ||||
| AHP τ (ms) | 28 | ±13 | 17 | ±5 | ↓ |
| 26 | 5 | ||||
| ADH amplitude (mV) | 2.6 | ±2.2 | 1.1 | ±0.7 | ↓ |
| 25 | 5 | ||||
| Conductance (nS) | 25 | ±13 | 33 | ±17 | — |
| 48 | 9 | ||||
| Ion (pA) | 659 | ±475 | 958 | ±512 | — |
| 36 | 9 | ||||
| Ioff (pA) | 737 | ±531 | 974 | ±580 | — |
| 36 | 9 | ||||
| ΔI (pA) (ms) | 78 | ±203 | 15 | ±159 | — |
| 36 | 9 | ||||
| F–Iasc (Hz nA−1) | 36 | ±16 | 37 | ±30 | — |
| 36 | 9 | ||||
| F–Idesc (Hz nA−1) | 37 | ±25 | 36 | ±28 | — |
| 36 | 9 | ||||
Shown here are the same properties as those in Tables 1 and 2, but comparing those motoneurons that had the largest total PIC amplitude (more than 1 SD above the mean) with the rest of the SOD1 motoneurons. The mean value ± SD for each group is listed with number of samples (n). The number of arrows in the rightmost column indicates significance, as follows: ↑ indicates 0.05 > P≥ 0.01; ↑↑ indicates 0.01 > P≥ 0.001; and ↑↑↑ indicates P < 0.001.