Figure 5. Expression of Ad-Nav1.5 promotes APD prolongation and EADs.

A, representative single-cell current-clamp AP recordings in each group. The AP plateau was prolonged and unstable in the Ad-Nav1.5 group, leading to the frequent occurrence of EADs (arrows). B, incidence of EADs (P < 0.05, χ² test). C, optical APD at 50% repolarization (APD₅₀) was significantly prolonged at all pacing cycle lengths in the Ad-Nav1.5 group vs. uninfected (†) or both uninfected and Ad-GFP (*); one-way ANOVA and Tukey's test (n = 3–18 monolayers).