Figure 2.

Overall functional activity and capacity were improved with IGF overexpression in Lama2^Dy-w mice. (A) Stand up test results showed a significant increase in exploratory behavior in Lama2^Dy-w+IGF-1tg mice than in Lama2^Dy-w mice (P< 0.005). (B) Pictures display leg extension and leg retraction in tail suspension tests performed to assess muscle weakness, with severity graded according to the average time to leg retraction (severe:<3 s; moderate: 3–6 s; mild: >6 s). Average muscle weakness was severe in Lama2^Dy-w mice and moderate in Lama2^Dy-w+IGF-1tg mice.