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. 2011 Apr 8;20(12):2406–2421. doi: 10.1093/hmg/ddr147

Figure 2.

Figure 2.

ApoE4 significantly impairs nerve regeneration following sciatic nerve injury. (A) Representative electron micrographs of cross-sections from adult sciatic nerves in apoE3 (E3) and apoE4 (E4) mice,1, 2 and 3 weeks after sciatic nerve crush. Scale bar = 10 μm. (B) Scatter plot (mean ± SEM) showing time course of axonal regeneration in apoE3 and apoE4 sciatic nerves following sciatic nerve crush. At both 2 and 3 weeks post-crush, apoE4 significantly delays regeneration (63 and 70% that of the levels of apoE3 axon regeneration at the same time points, respectively. 1 week, P> 0.05; t-test, two-tailed; apoE3, n= 3; apoE4, n= 2. 2 weeks, P< 0.05; t-test, two-tailed; apoE3, n= 6; apoE4, n= 6. 3 weeks, P< 0.05; t-test, two-tailed; apoE3, n= 11; apoE4, n= 11).