Table 2.

iTRAQ identification of proteins with >20% decreased expression and peptide count >1 in the unlesioned sciatic nerve from ApoE4 mice compared with ApoE3 mice

Protein name	Accession number	Protein MW	Protein PI	Peptide count	Total ion score, CI percentage	Best ion score	Average ratio (E4/E3)	Standard deviation (E4/E3)
Myosin, light polypeptide 6B	26986555	25852.8	5.4	4	100.00	69.41	0.19	0.12
Myoglobin	21359820	20131.1	7.1	10	100.00	143.49	0.49	0.07
Myosin, light polypeptide 3, isoform CRA_a	148677054	27359.4	5.0	5	100.00	54.09	0.51	1.25
h1-calponin alpha	1069994	36759.9	8.8	4	100.00	68.12	0.54	0.03
Igh protein	62028521	56919.8	7.5	3	100.00	71.06	0.57	0.08
Ig H-C allotype gamma2b	223428	40724.8	7.2	2	100.00	90.21	0.61	0.03
h-caldesmon	17017241	43428.3	5.3	2	100.00	70.01	0.63	0.25
Light chain of the monoclonal antibody MST2	1617395	27982.7	7.0	2	100.00	55.34	0.66	0.03
Skeletal muscle LIM protein	2880031	38678.1	8.8	2	100.00	78.07	0.67	0.02
Heat shock protein, alpha-crystallin-related, B6	59958370	18132.5	5.6	3	100.00	54.71	0.68	0.09
Chain A, crystal structure of mouse transthyretin	161172183	15211.9	5.8	3	100.00	94.87	0.69	0.08
Actinin alpha 2	157951643	112009.7	5.3	23	100.00	112.37	0.69	0.22
LIM domain binding 3 isoform b	84872213	76092.4	8.3	3	100.00	70.38	0.70	0.10
Filamin, alpha	125347376	305825.3	5.7	29	100.00	89.05	0.71	0.09
Fibromodulin precursor	10946680	44933.6	5.9	2	100.00	43.37	0.71	0.13
Milk fat globule-EGF factor 8 protein isoform 2	113865977	50796.5	6.7	5	100.00	83.22	0.71	0.08
Transgelin	6755714	25201.2	8.9	8	100.00	88.00	0.71	0.04
Myosin	1945080	253502.8	5.4	17	100.00	83.10	0.72	0.15
PDZ and LIM domain protein 3	7948997	36807.6	8.1	3	100.00	68.49	0.72	0.17
Myosin regulatory light polypeptide 9	198278553	22033.0	4.9	6	100.00	74.98	0.72	0.04
Collagen alpha-1(XIV) chain	146345398	206682.6	5.0	8	100.00	93.04	0.74	0.05
Procollagen, type I, alpha 2 precursor	111120329	136953.2	9.3	8	100.00	77.32	0.75	0.17
Destrin, isoform CRA_b	148696488	28666.5	9.0	5	100.00	66.15	0.76	0.08
LIM domain containing preferred translocation partner in lipoma isoform 1	225543157	71700.8	7.2	4	100.00	52.29	0.76	0.09
Actinin alpha 2	58476244	111806.5	5.3	20	100.00	112.37	0.76	0.27
Ig gamma-3 chain C region	121044	47963.7	6.7	3	100.00	46.58	0.76	0.03
Proteasome alpha 6 subunit	6755198	30608.7	6.3	3	100.00	75.58	0.77	0.21
Protein phosphatase 1	471976	42247.5	5.8	2	100.00	43.57	0.77	0.01
Chain A, crystal structure of the Ap-2 clathrin adaptor alpha	5822376	29953.4	6.9	2	100.00	49.31	0.78	0.06
Gfap protein	72679718	51278.8	5.1	3	100.00	45.03	0.78	0.19
Albumin precursor	163310765	77836.5	5.8	36	100.00	121.79	0.78	0.12
Probable ATP-dependent RNA helicase DDX5	2500527	74734.3	9.1	2	100.00	50.01	0.78	0.02
Adipsin precursor	7304867	29317.2	6.2	2	100.00	44.03	0.79	0.05
PDZ and LIM domain 5, isoform CRA_c	148680118	57492.2	8.2	3	100.00	82.11	0.79	0.09
Heterogeneous nuclear ribonucleoprotein L	183980004	68765.9	7.3	3	100.00	77.22	0.79	0.03
Fibulin 2	13529413	134192.5	4.6	2	100.00	43.20	0.79	0.02
EF hand domain containing 2	31981086	28253.9	5.0	2	100.00	43.24	0.79	0.17
Serpin peptidase inhibitor, clade C, member 1 precursor	18252782	57428.0	6.1	3	100.00	49.87	0.79	0.12
mKIAA0777 protein	28972395	139280.4	8.4	4	100.00	88.73	0.79	0.23
Carboxylesterase	192854	65222.7	5.0	8	100.00	84.01	0.80	0.11