Table 2.
Top ten PharmGKB gene, drug, disease and pathway pages for 2009.
| Rank | Genes | Drugs | Diseases | Pathways |
|---|---|---|---|---|
| 1 | CYP2D6 | Warfarin | Torsades de pointes | Platelet aggregation pathway (PD) |
| 2 | ABCB1 | Amiodarone | Breast neoplasms | Codeine and morphine pathway (PK) |
| 3 | CYP2C9 | Clopidogrel | Epilepsy | Nicotine pathway (PK) |
| 4 | CYP2C19 | Oxaliplatin | Precursor cell lymphoblastic, leukemia lymphoma | EGFR inhibitors pathway (PD) |
| 5 | CYP3A4 | Fluoxetine | Cardiovascular diseases | Antiplatelet drug clopidogrel pathway (PK) |
| 6 | VKORC1 | Capecitabine | Asthma | Bisphosphonate pathway |
| 7 | TPMT | Metoprolol | Stroke | ACE-inhibitor pathway (PD) |
| 8 | UGT1A1 | Imatinib | Hypertension | Warfarin pathway (PD) |
| 9 | CYP1A2 | Salbutamol | Type 2 diabetes mellitus | Warfarin pathway (PK) |
| 10 | CYP2B6 | Phenylephrine | Depression | Selective serotonin reuptake inhibitors pathway |
ACE: Angiotensin-converting enzyme; EGFR: EGR receptor; PD: Pharmacodynamics; PK: Pharmacokinetics.