Table 1.

Compounds that interact with P-glycoprotein

P-gp substrates

Actinomycin D, Aldosterone, ALLM peptide, ALLN peptide, Amitriptyline,    Amprenavir, Atorvastatin, β-amyloid, Bromperidol, Calcein acetoxymethylester,    Carbamazepine, Celiprolol, Chloropromazine, Clopidogrel, Cimetidine,    Citalopram, Colchicine, Corticosterone, Cortisol, Cyclosporine A,    Daunorubicin, Dexamethasone, Digoxin, Diltiazem, Docetaxel, Domperidon,    Doxycycline, Doxorubicin, Erythromycin, Etoposide, Fexofenadine, Grapefruit    juice, Gramacidin D, Gramacidin S, Imatinib, Indinavir, Irinotecan, Itraconazole,    Ivermectin, Ketoconazole, Lamotrigine, Lansoprazole, Levetiracetam,    Levofloxacin, Loperamide, Losartan, Lovastatin, Melphalan,    Methylprednisolone, Mevinolin, Mitomycin C, Mitoxantrone, Morphine,    Nelfinavir, Omeprazole, Ondansetron, Paclitaxel, Pantoprazole, Pentazocine,    Phenobarbital, Phenothiazine, Phenytoin, Propanolol, Quinidine, Ranitidine,    Rifampicin, Ritonavir, Saquinavir, short chain lipids, Simvastatin, Sirolimus,    Sparfloxacin, Tacrolimus, Talinolol, 99mTc-MIBI, Teniposide, Terfenadine,    Tetracycline, Topotecan, Valspodar, Vecuronium, Verapamil, Vinblastine,    Vincristine

P-gp inhibitors

Amiodarone, Amitriptyline, Astemizole, Atorvastatin, Bepridil, Biricodar,    Bromocriptine, Carotenoids, Carvedilol, Chlorpromazine, Clarithriomycin,    Cobalamin, Cortisol, Cremophor EL, Curcumin, Cyclosporine A, Desipramine,    Dietary antioxidants, Diltiazem, Dipyridamole, Disulfiram, Elacridar, Erlotinib,    Erythromycin, Felodipine, Fluoxetine, Flupenthixol, Fluphenazine, Gefitinib,    Haloperidol, Indinavir, Itraconazole, Ketoconazole, Laniquidar, Lansoprazole,    Leupeptin, Lonafarnib, Maprotiline, Mefloquine, Midazolam, Mifepristone,    Natural diterpenes, Natural triterpenes, Nelfinavir, Nicardipine, Nitrendipine,    ONT-093, Omeprazole, Pantoprazole, Paroxetine, Pentazocine, Progesterone,    Propafenone, Quinidine, Quinine, Reserpine, Ritonavir, Saquinavir, Sertraline,    Simvastatin, Sirolimus, Spironolactone, Tacrolimus, Tamoxifen, Tariquidar,    Terfenadine, Tetrabenzine, Tocopherol, Valinomycin, Valspodar, Vanadate,    Verapamil, Vinblastine, XR9051, Zosuquidar

P-gp inducers/stimulators

Amiodarone, Amprenavir, Bromocriptine, Chlorambucil, Cisplatin, Clotrimazole,    Colchicine, Cyclosporine A, Daunorubicin, Dexamethasone, Diltiazem,    Doxorubicin, Efavirenz, Erythromycin, Etoposide, FCME peptide, Flurouracil,    GGCME peptide, Hydroxyurea, Insulin, Indinavir, Methotrexate, Midazolam,    Mitoxantrone, Morphine, Nelfinavir, Nicardipine, Nifedipine, Phenytoin,    Phenothiazine, Prenylcysteines, Probenecid, Reserpine, Retinoid acid,    Rifampicin, Ritonavir, Saquinavir, St John’s wort, Tacrolimus, Tamoxifen,    Verapamil, Vinblastine, Vincristine, Yohimbine

References: [3,5,10,22,43,50–72]