Table 2.
Analysis | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | ||||||
mean | sd | mean | sd | mean | sd | mean | sd | mean | sd | |
#found genes | 0 | 0 | 10 | 85 | 164 | 437 | 1033 | 928 | 2404 | 915 |
FDR | 0.003 | 0.055 | 0.029 | 0.119 | 0.048 | 0.145 | 0.034 | 0.061 | 0.028 | 0.006 |
APR | 0.000 | 0.000 | 0.002 | 0.016 | 0.032 | 0.085 | 0.200 | 0.180 | 0.467 | 0.178 |
0.043 | 0.060 | 0.038 | 0.120 | 0.049 | 0.134 | 0.241 | 0.208 | 0.518 | 0.174 | |
(S) | 0.055 | 0.122 | 0.025 | 0.085 | 0.037 | 0.092 | 0.220 | 0.188 | 0.488 | 0.172 |
(L) | 0.283 | 0.401 | 0.382 | 0.228 | 0.410 | 0.132 | 0.581 | 0.113 | 0.708 | 0.079 |
6 | 7 | 8 | 9 | 10 | ||||||
mean | sd | mean | sd | mean | sd | mean | sd | mean | sd | |
#found genes | 3414 | 637 | 3894 | 520 | 4092 | 471 | 4155 | 451 | 4167 | 446 |
FDR | 0.027 | 0.004 | 0.027 | 0.004 | 0.027 | 0.004 | 0.027 | 0.004 | 0.027 | 0.004 |
APR | 0.664 | 0.124 | 0.757 | 0.101 | 0.796 | 0.092 | 0.808 | 0.088 | 0.811 | 0.087 |
0.698 | 0.096 | 0.778 | 0.062 | 0.812 | 0.043 | 0.823 | 0.034 | 0.825 | 0.031 | |
(S) | 0.671 | 0.117 | 0.756 | 0.098 | 0.790 | 0.091 | 0.802 | 0.087 | 0.804 | 0.086 |
(L) | 0.797 | 0.056 | 0.847 | 0.042 | 0.870 | 0.031 | 0.877 | 0.025 | 0.878 | 0.023 |
The descriptive values for each interim analysis including the number detected genes, the simulated FDR, the real APR, and the APR estimates, all in the setting of τ = 50% altered genes with large fold changes and ten interim analyses. These values correspond to Figure 4 (b) and Figure 5 (b).