Table 2.

AQP1, -3, -4, -5 and -9 gene expression in 105 NSCLC and normal samples by qRT-PCR data

AQP isoform	Tumor vs Normal		AC vs SCC		AC MT vs MN		SCC MT vs MN		Survival in AC: Good vs Bad
	p-value	Fold change	p-value	Fold change	p-value	Fold change	p-value	Fold change	p-value	Fold change
AQP1	0.0000	0.22	0.0228	2.36	0.0000	0.26	0.0000	0.10	0.0340	2.86
AQP3	0.7089	0.93	0.0005	5.81	0.0205	1.76	0.0676	0.38	0.7165	0.81
AQP4	0.0000	0.11	0.0144	5.96	0.0000	0.12	0.0002	0.02	0.0344	4.42
AQP5	0.0253	0.50	0.3255	1.88	0.1640	0.55	0.1956	0.39	0.1937	0.25
AQP9	0.7384	1.05	0.1310	0.64	0.6103	0.91	0.7887	1.12	0.7480	1.15

Student's T-Test comparison between matched tumor (MT) and normal lung tissue (MN) collectives (n = 45), different histology (AC vs SCC) and survival (good >3 y, bad <3 y).

AQP: aquaporin; AC: adenocarcinoma; SCC: squamous cell carcinoma; p-value and fold change in bold indicate statistical significance.