Table 3.
Human cancer-associated lncRNAs
| LncRNA | Size | Cytoband | Cancer types | References |
|---|---|---|---|---|
| HOTAIR | 2158 nt | 12q13.13 | Breast | [18,68] |
| MALAT1/α/NEAT2 | 7.5 kb | 11q13.1 | Breast, lung, uterus, pancreas, colon, prostate, liver, cervix1, neuroblastoma1, osteosarcoma | [135,137-139,152,255,256] |
| HULC | 500 nt | 6p24.3 | Liver, hepatic colorectal metastasis | [170,171] |
| BC200 | 200 nt | 2p21 | Breast, cervix, esophagus, lung, ovary, parotid, tongue | [50,51] |
| H19 | 2.3 kb | 11p15.5 | Bladder, lung, liver, breast, endometrial, cervix, esophagus, ovary, prostate, choricarcinoma, colorectal | [74,92,95,97,102,103,257-264] |
| BIC/MIRHG155/MIRHG2 | 1.6 kb | 21q11.2 | B-cell lymphoma | [153] |
| PRNCR1 | 13 kb | 8q24.2 | Prostate | [187] |
| LOC285194 | 2105 nt | 3q13.31 | Osteosarcoma | [265] |
| PCGEM1 | 1643 nt | 2q32.2 | Prostate | [188,266,267] |
| UCA1/CUDR | 1.4 kb, 2.2 kb, 2.7 kb | 19p13.12 | Bladder, colon, cervix, lung, thyroid, liver, breast, esophagus, stomach | [268-270] |
| DD3/PCA3 | 0.6 kb, 2 kb, 4 kb | 9q21.22 | Prostate | [189,190] |
| anti-NOS2A | ~1.9 kb | 17q23.2 | Brain1 | [271] |
| uc.73A | 201 nt | 2q22.3 | Colon | [200] |
| TUC338 (encodes uc.338) | 590 nt | 12q13.13 | Liver | [203] |
| ANRIL/p15AS/CDK2BAS | 34.8 kb & splice variants | 9p21.3 | Prostate, leukemia | [175,176,183,272] |
| MEG3 | 1.6 kb & splicing isoforms | 14q32.2 | Brain (downregulated) | [156-158,162] |
| GAS5/SNHG2 | Multiple isoforms | 1q25.1 | Breast (downregulated) | [273] |
| SRA-1/SRA (bifunctional) | 1965 nt | 5q31.3 | Breast, uterus, ovary (hormone responsive tissue) | [274,275] |
| PTENP1 | ~3.9 kb | 9p13.3 | Prostate | [173,174] |
| ncRAN | 2186 nt, 2087 nt | 17q25.1 | Bladder, neuroblastoma | [276,277] |
1 Cell lines