Table 4. Unadjusted and adjusted linear regression coefficients of sex-specific quintiles of uric acid (95% CI) on log of inflammatory markers in females.

		Q1	Q2	Q3	Q4	Q5	P-trend
Serum uric acid (µmol/L)		193	233	263	298	357
IL-1β (pg/mL)	Unadjusted	Ref	−0.01	−0.15	−0.13	−0.34	<0.001
			(−0.19;0.17)	(−0.33;0.03)	(−0.31;0.05)	(−0.52;−0.16)
	Fully adjusted	Ref	0.01	−0.09	−0.03	−0.18	0.106
			(−0.17;0.19)	(−0.27;0.10)	(−0.21;0.16)	(−0.39;0.02)
	Fully adjusted excluding BMI	Ref	0.01	−0.09	−0.04	−0.21	0.050
			(−0.17;0.19)	(−0.27;0.09)	(−0.22;0.15)	(−0.40;−0.01)
IL-6(pg/mL)	Unadjusted	Ref	−0.10	0.08	0.11	0.28	<0.001
			(−0.26;0.06)	(−0.08;0.25)	(−0.05;0.27)	(0.11;0.44)
	Fully adjusted	Ref	−0.11	0.03	0.02	0.08	0.179
			(−0.28;0.05)	(−0.13;0.20)	(−0.15;0.19)	(−0.10;0.27)
	Fully adjusted excluding BMI	Ref	−0.10	0.07	0.10	0.22	0.002
			−0.26;0.06)	(−0.09;0.24)	(−0.07;0.27)	(0.04;0.39)
TNF-α (pg/mL)	Unadjusted	Ref	0.06	0.14	0.19	0.26	<0.001
			(−0.04;0.16)	(0.04;0.24)	(0.08;0.29)	(0.16;0.36)
	Fully adjusted	Ref	0.04	0.08	0.09	0.09	0.065
			(−0.06;0.14)	(−0.02;0.18)	(−0.01;0.20)	(−0.02;0.21)
	Fully adjusted excluding BMI	Ref	0.04	0.10	0.13	0.16	0.001
			(−0.06;0.14)	(0.00;0.20)	(0.03;0.23)	(0.05;0.27)
CRP (mg/L)	Unadjusted	Ref	0.07	0.30	0.52	0.92	<0.001
			(−0.04;0.19)	(0.18;0.42)	(0.40;0.64)	(0.80;1.04)
	Fully adjusted	Ref	0.04	0.15	0.23	0.39	<0.001
			(−0.07;0.15)	(0.04;0.26)	(0.11;0.34)	(0.27;0.51)
	Fully adjusted excluding BMI	Ref	0.08	0.27	0.48	0.80	<0.001
			(−0.03;0.20)	(0.16;0.39)	(0.36;0.60)	(0.67;0.93)

*median value of serum uric acid in each quintile. IL-1β = interleukin-1β; IL-6 = interleukin-6: TNF-α = tumour necrosis factor-alpha; CRP = ultrasensitive C-reactive protein.

Adjusted for age, alcohol intake, smoking, BMI, GFR (calculated according to Modification in Diet in Renal Disease equation), diabetes, hypertension & use of diuretics.