Table 4. Unadjusted and adjusted linear regression coefficients of sex-specific quintiles of uric acid (95% CI) on log of inflammatory markers in females.
Q1 | Q2 | Q3 | Q4 | Q5 | P-trend | ||
Serum uric acid (µmol/L) | 193 | 233 | 263 | 298 | 357 | ||
IL-1β (pg/mL) | Unadjusted | Ref | −0.01 | −0.15 | −0.13 | −0.34 | <0.001 |
(−0.19;0.17) | (−0.33;0.03) | (−0.31;0.05) | (−0.52;−0.16) | ||||
Fully adjusted | Ref | 0.01 | −0.09 | −0.03 | −0.18 | 0.106 | |
(−0.17;0.19) | (−0.27;0.10) | (−0.21;0.16) | (−0.39;0.02) | ||||
Fully adjusted excluding BMI | Ref | 0.01 | −0.09 | −0.04 | −0.21 | 0.050 | |
(−0.17;0.19) | (−0.27;0.09) | (−0.22;0.15) | (−0.40;−0.01) | ||||
IL-6(pg/mL) | Unadjusted | Ref | −0.10 | 0.08 | 0.11 | 0.28 | <0.001 |
(−0.26;0.06) | (−0.08;0.25) | (−0.05;0.27) | (0.11;0.44) | ||||
Fully adjusted | Ref | −0.11 | 0.03 | 0.02 | 0.08 | 0.179 | |
(−0.28;0.05) | (−0.13;0.20) | (−0.15;0.19) | (−0.10;0.27) | ||||
Fully adjusted excluding BMI | Ref | −0.10 | 0.07 | 0.10 | 0.22 | 0.002 | |
−0.26;0.06) | (−0.09;0.24) | (−0.07;0.27) | (0.04;0.39) | ||||
TNF-α (pg/mL) | Unadjusted | Ref | 0.06 | 0.14 | 0.19 | 0.26 | <0.001 |
(−0.04;0.16) | (0.04;0.24) | (0.08;0.29) | (0.16;0.36) | ||||
Fully adjusted | Ref | 0.04 | 0.08 | 0.09 | 0.09 | 0.065 | |
(−0.06;0.14) | (−0.02;0.18) | (−0.01;0.20) | (−0.02;0.21) | ||||
Fully adjusted excluding BMI | Ref | 0.04 | 0.10 | 0.13 | 0.16 | 0.001 | |
(−0.06;0.14) | (0.00;0.20) | (0.03;0.23) | (0.05;0.27) | ||||
CRP (mg/L) | Unadjusted | Ref | 0.07 | 0.30 | 0.52 | 0.92 | <0.001 |
(−0.04;0.19) | (0.18;0.42) | (0.40;0.64) | (0.80;1.04) | ||||
Fully adjusted | Ref | 0.04 | 0.15 | 0.23 | 0.39 | <0.001 | |
(−0.07;0.15) | (0.04;0.26) | (0.11;0.34) | (0.27;0.51) | ||||
Fully adjusted excluding BMI | Ref | 0.08 | 0.27 | 0.48 | 0.80 | <0.001 | |
(−0.03;0.20) | (0.16;0.39) | (0.36;0.60) | (0.67;0.93) |
*median value of serum uric acid in each quintile. IL-1β = interleukin-1β; IL-6 = interleukin-6: TNF-α = tumour necrosis factor-alpha; CRP = ultrasensitive C-reactive protein.
Adjusted for age, alcohol intake, smoking, BMI, GFR (calculated according to Modification in Diet in Renal Disease equation), diabetes, hypertension & use of diuretics.