Table 1. Association results for the three most significantly associated loci.

Gene	Locus	SNP	SNP function	coded allele	Coded allele frequency	N eff	Beta	Se	P
FEV1 All individuals
MACROD2	20p12.1	rs204652	Intron	G	0.983	13551	−0.187	0.047	6.81×10−5
CNTN5	11q21-q22.2	rs17133553	Intron	T	0.966	13669	−0.100	0.029	4.37×10−4
MTHFD1L	6q25.1	rs803450	Intron	G	0.625	18497	0.036	0.011	1.03×10−3
FEV1 Smokers
SERPINA1	14q32.13	rs3748312	Intron	T	0.167	9338	0.085	0.022	8.41×10−5
PDE4D	5q12	rs298028	Intron	T	0.283	10829	−0.069	0.018	1.22×10−4
MACROD2	20p12.1	rs204652	Intron	G	0.983	6872	−0.251	0.067	1.67×10−4
FEV1/FVC All individuals
ABCC1	16p13.1	rs3887893	Intron	T	0.625	15509	−0.043	0.012	4.38×10−4
ESR1	6q25.1	rs11155818	Intron	G	0.992	12571	0.185	0.053	5.02×10−4
CNTN5	11q21-q22.2	rs1216170	Intron	C	0.284	18863	0.039	0.011	6.02×10−4
FEV1/FVC Smokers
ESR1	6q25.1	rs9322335	Intron	T	0.217	9495	−0.061	0.018	5.42×10−4
RHBDD1	2q36.3	rs1864271	Intron	G	0.708	7385	0.066	0.019	6.40×10−4
MTHFD1L	6q25.1	rs1738567	Intron	C	0.367	10668	0.046	0.014	1.33×10−3

The table shows the three most significant loci associated with FEV₁ and FEV₁/FVC ratio in all individuals and ever-Smokers. N eff: the effective sample size. Beta: regression coefficient on a transformed scale. Se: standard error. P: P value. Coded allele frequency based on HapMap Release 24. MACROD2: MACRO domain containing 2. CNTN5: Contactin 5. MTHFD1L Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. SERPINA1: serpin peptidase inhibitor, clade A, member 1 (alpha-1 antitrypsin AAT). PDE4D: Phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila). ABCC1: ATP-binding cassette, sub-family C, member 1. ESR1: estrogen receptor 1. RHBDD1: rhomboid domain containing 1.