Table 2. Association results for the most significant loci excluding genes identified in GWAS.

gene	locus	SNP	SNP function	coded allele	Coded allele Frequency	N eff	Beta	se	P
FEV1 All
PDE4D	5q12	rs172362	Intron	C	0.133	18929	−0.048	0.015	1.36×10−3
TRPV4	12q24.1	rs3742030	Missense	G	0.992	17591	−0.110	0.035	1.58×10−3
NAT2	8p22	rs6988857	Intergenic	T	0.241	20080	0.035	0.011	2.37×10−3
FEV1 Smokers
SERPINA1	14q32.13	rs3748312	Intron	T	0.167	9338	0.085	0.022	8.41×10−5
PDE4D	5q12	rs298028	Intron	T	0.283	20829	−0.069	0.018	1.22×10−4
BCL2	18q21.3	rs2850760	Intron	T	0.425	10888	0.050	0.014	4.66×10−4
FEV1/FVC All
ABCC1	16p13.1	rs3887893	Intron	T	0.625	15509	−0.043	0.012	4.38×10−4
ESR1	6q25.1	rs11155818	Intron	G	0.992	12571	0.185	0.053	5.02×10−4
AIF1	6p21.3	rs3132451	5′near gene	G	0.883	19889	0.045	0.014	7.84×10−4
FEV1/FVC Smokers
ESR1	6q25.1	rs9322335	Intron	T	0.217	9495	−0.061	0.018	5.42×10−4
ABCC1	16p13.1	rs3887893	Intron	T	0.625	8156	−0.054	0.017	1.36×10−3
CD22	19q13.1	rs7251526	Intron	T	0.246	8328	−0.054	0.018	2.00×10−3

The table shows association results for the three most significant loci associated with FEV₁ and FEV₁/FVC, in all individuals and in ever-smokers after excluding genes identified in GWAS. N eff: the effective sample size. Beta: regression coefficient on a transformed scale. Se: standard error. P: P value. Coded allele frequency based on HapMap Release 24. PDE4D: Phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila). TRPV4: transient receptor potential cation channel, subfamily V, member 4. NAT2: N-acetyltransferase 2. SERPINA1: serpin peptidase inhibitor, clade A, member 1 (alpha-1 antitrypsin AAT). BCL2: B-cell CLL/lymphoma 2. ABCC1: ATP-binding cassette, sub-family C, member 1. AIF1: allograft inflammatory factor 1. ESR1: estrogen receptor 1. CD22: cluster of differentiation; CD22 molecule.