Table 3. Relative increases in brain activity associated with personal familiarity.
| Region | Side | x | y | z | T-Score | kE (voxels) |
| Simple main effect familiarity: (FF+FP)-(UF+UP) | ||||||
| Control subjects | ||||||
| Anterior cingulate | L | −9 | 45 | 17 | 7.11 | 5553# |
| Posterior cingulate | L | −12 | −51 | 30 | 6.67 | # |
| Middle frontal gyrus | L | −24 | 30 | 39 | 4.67 | 102 |
| Inferior frontal gyrus | L | −30 | 24 | −18 | 5.07 | 133 |
| Inferior frontal gyrus | L | −51 | 6 | 12 | 4.62 | 174 |
| Precentral gyrus | L | −33 | −12 | 51 | 4.62 | 219 |
| Inferior parietal lobule | L | −36 | −42 | 45 | 4.25 | 108 |
| Cerebellum | R | 33 | −54 | −51 | 5.58 | 130 |
| Inferior temporal gyrus | R | 51 | −51 | 3 | 5.17 | 151 |
| aMCI patients | ||||||
| Precuneus | L | −6 | −61 | 35 | 4.29 | 174 |
| R | 6 | −61 | 29 | 3.68 | # | |
| Group comparison (interaction group*familiarity) | ||||||
| Controls>aMCI | ||||||
| Inferior frontal gyrus | R | 45 | 20 | 8 | 4.90 | 709 |
| Medial frontal gyrus | R | 39 | 53 | 8 | 4.89 | # |
All activations are significant at p<0.05, corrected for multiple comparisons at the cluster level (with a height threshold of p<0.001, uncorrected at the voxel level). For each region of activation, the coordinates of the maximally activated voxels within the activation cluster are given in standard stereotactic MNI space. FF: familiar faces, UF: unfamiliar faces, FP: familiar places, UP: unfamiliar places; # indicates that this activation maximum is part of the same cluster.