S represents the signal sequence while A and A' regions stand for putative ligand-binding A region. B1, B2, B3, B4, B5, B1′ and B2′ designate single B repeat. A'N and A'C are flanking regions of the insertion sequence which are identical to the N-terminus and the C-terminus of SdrC_ED133 A region, respectively; IS denotes an insertion sequence in the A region of SdrC_ED133; sdrH-N and sdrH-C represent flanking regions of the 3 repeats insertion sequence which are identical with N-terminus and the C-terminus of SdrH_O&W; IS' represents 3x repeats insertion sequence in sdrH mutant. 102 and 161 are the locations for the insertion. SdrC_Q&E represent the normal SdrC proteins in isolates from Quebec and East Canada; SdrC_mutant1 represents the insertion sequence found in SdrC in Canadian isolates E48, E49 and E50. SdrC_mutant2 represents the deletion sequence found in SdrC in Canadian isolates E5-16, CE6-14, CE16 and CE18; SdrD represents the normal SdrD proteins in Canadian isolates; SdrD_mutant represents the deletion sequence found in SdrD in Canadian isolates Q14, Q17, E7, E13, E21-24, E28-30, E45, E48, CE6-10, CE13, CE16, CE18-23, CE28, O3, O4, O18-20, CO4, CO7, CO8, CO11, CO16, CO18, CO20, O3, O4, O18-20, W9, W13, W15, W16, W20-23, W25, W32, W33, W35-37, W39, W40, CW3, CW4 and CW18; SdrH_O&W represents the normal SdrH proteins in isolates from Ontario and Western Canada; SdrH_mutant represents the insertion sequence found in SdrH in Ontario and Western Canada isolates O21-24.