Figure 8. Special behavioural deficits in male but not female aspa^lacZ/lacZ mutants.

A. Analysis of motor coordination in the rotarod test shows impairment of both female and male aspa^lacZ/lacZ mice compared with their aspa^+/+ controls at P90. B. Spontaneous exploratory activity and aspects of anxiety-related behaviour of both sexes and genotypes were tested in an open field for 30 min (see Methods section). Male mutants (n = 8) travelled less and spent more time in the centre than male controls (n = 8). This behaviour is suggestive of impaired exploratory activity and anxiolysis. The behaviour of female mutants (n = 6) did not differ from female controls (n = 7).