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. 2011 May 17;5(5):e1050. doi: 10.1371/journal.pntd.0001050

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Aparicio-Burgos et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Dogs were vaccinated, and challenged with T. cruzi. Heart tissue sections (5-ìM) from left ventricle, septum, and right ventricle were obtained at 60 days post-infection (acute phase), and stained with hematoxylin-eosin. Shown are representative micrographs of dogs injected with vector only (B,B1,B2) or immunized with TcVac1 (C,C1,C2). Micrographs from normal/uninfected dogs (A,A1,A2) are shown for comparison. Vertical arrows show amastigote nests and horizontal arrows show lymphocyte infiltration, and cardiomyocytes destruction.