Table 4.

Key residues for CDR detection. Underlined residues denote additional residues that must be incorporated into the classical antibody CDR identification rules (32) in order to detect cAb CDRs. Brackets enclose multiple residues codes that appear at each sequence position. X indicates any of the 20 amino acids.

CDR Loop	Chothia Definition(32)	Starting Position	Preceded By	Length(Residues)		Followed By
				Classical	Camelids
H1	H26-H35	After first Cys	CXXX	10-12	7-13	W[IVFYAMLND][RKQVNC][QKHELR]
H2	H50-H56	Always 15 residues after H1 end	[WYLAFGS][ILVM][GASV]	7,8,10	6-13	XX[YFLS]XXXX[QKRES]
H3	H95-102	Always 33 residues after H2 end	CXX	3-22	8-24	[WR]GX[GRDS]