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. Author manuscript; available in PMC: 2012 May 20.
Published in final edited form as: ACS Chem Biol. 2011 Feb 16;6(5):432–443. doi: 10.1021/cb100253e

Figure 6. Effect of C48 on Stat3- and Stat1-mediated transcriptional activity.

Figure 6

A) Effect of C48 on Oncostatin M (OSM)-induced, Stat3-mediated expression of luciferase as a measure of transcription activity. Serum-starved HeLa-Stat3-Luc cells were pre-incubated with C48 1 h prior to stimulation with OSM. Luminescence was measured 8 h post stimulation. B) Effect of C48 on IFNγ-induced, Stat1-mediated expression of luciferase as a measure of transcription activity. Serum-starved HeLa-Stat1-Luc cells were pre-incubated with C48 1 h prior to stimulation with IFNγ. Luminescence was measured 8 h post stimulation. One representative result is shown (n=3, in triplicate).