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. Author manuscript; available in PMC: 2012 May 20.
Published in final edited form as: ACS Chem Biol. 2011 Feb 16;6(5):432–443. doi: 10.1021/cb100253e

Figure 8. Effect of C48 on in vivo growth of a human breast tumor xenograft and a syngeneic mouse model of murine breast adenocarcinoma.

Figure 8

A) Breast tumor xenograft mouse model. Tumor volume of MDA-MB-468 tumor-bearing mice treated once daily for 5 days a week with C48 (white circle) at 200 mg kg-1 (delivered i.p.) or vehicle (black circle) until termination of the experiment (day 66). B) Syngeneic mouse model. Tumor volume of C3L5 tumor-bearing mice treated (i.p.) once daily for 5 days a week with C48 at 100 mg kg-1 (black circle) or 200 mg kg-1 (black diamond), or vehicle control (white circle) until termination of the experiment (day 26). Results are presented as mean tumor volume (n=8). Bars represent standard error. *, P< 0.05 when vehicle-treated control group is compared to 200 mg kg-1 C48-treated group.