Table 3.
Cut off values of antipneumococcal antibodies for the diagnosis of SPAD as defined by Jeurissen et al. [31] and Borgers et al. [4] in relation to serotypes in pneumococcal conjugate vaccines
| Pneumococcal serotype | Serotypes of pneumococcal conjugate vaccine | Anti-pneumococcal antibodies by ELISA (mg/L)a | Anti-pneumococcal antibodies by multiplex bead assay (mg/L)a | ||||
|---|---|---|---|---|---|---|---|
| PCV-7 | PCV-10 | PCV-13 | Age | Age | Age | Age | |
| 3–15 years | 19–30 years | 3–30 years | 3–30 years | ||||
| 1 | x | x | 0.53 | ||||
| 3 | x | 0.99 | 0.58 | 0.67 | 0.64 | ||
| 4 | x | x | x | 0.73 | 0.37 | 0.45 | 0.49 |
| 6B | x | x | x | 0.80 | |||
| 7F | x | x | 1.45 | ||||
| 8 | 1.02 | ||||||
| 9N | 0.78 | 0.23 | 0.46 | 0.63 | |||
| 9V | x | x | x | 0.69 | |||
| 12F | 0.46 | ||||||
| 14 | x | x | x | 0.57 | |||
| 18C | x | x | x | 0.55 | 0.31 | 0.31 | 0.34 |
| 19A | x | 0.96 | |||||
| 19F | x | x | x | 1.66 | 0.91 | 1.04 | 0.74 |
| 23F | x | x | x | 0.24 | |||
Serotypes present in 23-valent pneumococcal polysaccharide (1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, and 33F)
aFifth percentile of normal controls
x serotypes cannot be used for the interpretation of the pneumococcal polysaccharide response, if the child received one of the PCV, PCV pneumococcal conjugate vaccines, ELISA enzyme-linked immunosorbent assay