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. 2011 Jan 31;589(Pt 7):1587–1601. doi: 10.1113/jphysiol.2011.204362

Figure 3. Inhibition of eEPSC by IEM-1925 is frequency dependent.

Figure 3

A, representative recordings in giant striatal interneuron at two different stimulation frequencies: 0.33 and 0.033 Hz. B, the traces from panel A are normalized to the corresponding control amplitude. C, pooled data from 6 independent experiments in giant striatal interneurons. An increase of stimulation frequency results in enhancement of eEPSC inhibition by IEM-1925. D, representative examples of eEPSC trains evoked every 5 s and 60 s in cortical FSIs; only first 8 responses out of 20 are shown. E, summary graph showing the difference in the block of eEPSC amplitude by IEM-1925 in trains delivered with different delays. In both types of experiments the decrease of channel activity resulted in significant decrease of blocking action. (***P < 0.001).