Figure 12. Representative experiments demonstrating the role of the ArcN in the effect of insulin to increase LSNA baroreflex gain.
Microinjection of muscimol (top) into the ArcN (continuous grey line, white circles) reverses the effect of i.v. insulin (continuous grey line, grey circles) to increase LSNA baroreflex gain compared to control (continuous black line, black circles). Microinjection of insulin in ArcN (bottom) with doses of 6 nU (continuous grey line, white circles) and 60 nU (continuous grey line, grey circles) increases baroreflex gain of LSNA compared to control (continuous black line, black circles).