Figure 8. Compliance of the aganglionic ls/ls colorectum did not differ from that of the control C57BL/6 bowel.
A, typical example of force generated during ramp distension by imposed changes in length (100 μm s−1, 4 mm) with averaged traces shown in B. C, typical example of lengthening of control colorectum evoked by a 40 g load (distension by imposed load) with averaged data in D not showing any difference between control and ls/ls mice. Changes in compliance are unlikely to explain different stimulus–response functions of mechanoreceptors between control and mutant mice.